Selected Publications

1. Rajauria, S., C. Axline, C. Gottstein, A.N. Cleland (2014) High-speed discrimination and sorting of submicron particles using a microfluidic device. Nano Lett., Just Accepted Manuscript • Publication Date (Web): 02 Dec 2014 Nanoletters 2014 - PDF


2. Gottstein, C, G. Wu, B.J. Wong, J.A. Zasadzinski (2013)  Precise quantification of nanoparticle internalization. ACS Nano 7:4933-45. ACS Nano 2013 - PDF___ ACS Nano 2013 - Suppl. 1___ ACS Nano 2013 - Suppl. 2___ ACS Nano 2013 - Suppl. 3___ ACS Nano 2013 - Feature as Spotlight on Nanowerk.com


3. Dane, K.Y., C. Gottstein, P.S. Daugherty (2009)  Cell surface profiling with peptide libraries yields ligand arrays that classify breast tumor subtypes. Molecular Cancer Therapeutics 8: 1312-1318. MCT 2008 - PDF MCT 2008 - Supplements


4. Ding, B.S., N. Hong, M. Christofidou-Solomidou, C. Gottstein, S.M. Albelda, D.B. Cines, A.B. Fisher, V.R. Muzykantov (2009) Anchoring Fusion Thrombomodulin to the Endothelial Lumen Protects against Injury-induced Lung Thrombosis and Inflammation. American Journal of Respiratory and Critical Care Medicine 180: 247-256. AJRCCM 2009 - PDF


5. Gosk, S., T. Moos, C. Gottstein/G. Bendas (2007) VCAM-1 directed immunoliposomes selectively target tumour vasculature in vivo. Biochimica et Biophysica Acta 1778:854-863 BBA 2008 - PDF


6. Ding, B.S., N.Hong, J-C. Murciano, K. Ganguly, C. Gottstein, M. Christofidou-Solomidou, S.M. Albelda, A.B. Fisher, D.B. Cines, V.R. Muzykantov (2007) Prophylactic thrombolysis by thrombin-activated latent pro-urokinase targeted to PECAM-1 in the pulmonary vasculature. Blood, Nov 28 2007, PMID 18045968, epub ahead of print. Blood 2007 - PDF


7. Danielyan, K., B.S. Ding, C. Gottstein, D.B. Cines, V.R. Muzykantov (2007) Delivery of anti-platelet-endothelial cell adhesion molecule single-chain variable fragment-urokinase fusion protein to the cerebral vasculature lyses arterial clots and attenuates postischemic brain edema.Journal of Pharmacology and Experimental Therapy 321:947-52. JPET 2007 - PDF JPET cover


8. Dienst, A., A. Grunow, M. Unruh, B. Rabausch, J.E. Nor, J.W.U. Fries, C. Gottstein (2005) Specific occlusion of murine and human tumor vasculature by VCAM-1 targeted recombinant fusion proteins. Journal of the National Cancer Institute, 97:733-747. JNCI 2005 - PDF JNCI Editorial - PDF


9. Ding, B.S./Gottstein C., A. Grunow, A. Kuo, K. Ganguly, S.M. Albelda, D.B. Cines, V.R. Muzykantov (2005) Endothelial targeting of a recombinant construct fusing a PECAM-1 single-chain variable antibody fragment (scFv) with prourokinase facilitates prophylactic thrombolysis in the pulmonary vasculature.Blood 106: 4191-4198. Blood 2005 - PDF


10. Gosk, S., C. Gottstein, G. Bendas (2005) Targeting of immunoliposomes to endothelial cells expressing VCAM: a future strategy in cancer therapy. Int J Clin Pharmacol Ther 43: 581-582. Int J Clin Pharmacol Ther 2005 - PDF


11. Unruh, M., A. Grunow, C. Gottstein (2005) Systemic coagulation parameters in mice after treatment with vascular targeting agents. Thrombosis Journal 3:21-33. Thrombosis Journal 2005 - PDF


12. Joussen, A., B. Kirchhof, C. Gottstein (2003) Molecular mechanisms of vasculogenesis and angiogenesis. [Molekulare Mechanismen der Vaskulogenese und Angiogenese.] Der Ophtalmologe 100: 284-291. Der Opthalmologe 2003 - PDF


13. Borchmann P., J.F. Treml, H. Hansen, C. Gottstein, R. Schnell, O. Staak, H.F. Zhang, T. Davis, T. Keler, V. Diehl, R.F. Graziano, A. Engert (2003) The new fully human anti-CD30 antibody 5F11 shows in vitro and in vivo activity against Hodgkin lymphoma. Blood 102: 3737-3742. Blood 2003 - PDF


14. Philipp, J., A. Dienst, M. Unruh, A. Wagener, A. Grunow, A. Engert, J.W.U. Fries, C. Gottstein (2003) Soluble tissue factor induces coagulation on tumor endothelial cells in vivo if coadministered with low-dose lipopolysaccharides. Arteriosclerosis Thrombosis and Vascular Biology 23:905-910. ATVB 2003 - PDF


15. Gottstein, C., R. Forde (2002) Affinity chromatography system for parallel purification of recombinant proteins. Protein Engineering 15: 775-777. Protein Engineering 2002 - PDF


16. Tur, M.K., S. Sasse, M. Stocker, K. Djabelkhir, M. Huhn, B. Matthey, C. Gottstein, T. Pfitzner, A. Engert, S. Barth (2001) An anti-GD2 single chain Fv selected by phage display and fused to Pseudomonas exotoxin A develops specific cytotoxic activity against neuroblastoma derived cell lines. International Journal of Molecular Medicine 8: 579-584 Int J Mol Med 2001 - PDF


17. Forde R., C. Gottstein, D. Lange. (2001) Improved analytical methodology for the detection of cryptosporidium and giardia. International Environmental Technology 11: 37-39.


18. Gottstein, C., W. Wels, B. Ober, P.E. Thorpe (2001) Generation and characterization of recombinant Vascular Targeting Agents from hybridoma cell lines. Biotechniques 30: 190-200. Biotechniques 2001 - PDF


19. Gottstein, C. (2000) Blood vessels – Target for Cancer Therapy [Blutgefäße – Zielscheibe für die Tumortherapie] Target Forum 3: 4-13.


20. Gottstein, C., R. Forde (1999) In vivo measurement of biodistribution kinetics of radiolabeled compounds in laboratory animals. Biotechniques 27: 934-938.


21. Schiefer, D., C. Gottstein, V. Diehl, A. Engert. (1999) Antiangiogenesis: A new Approach for Cancer Therapy? [Antiangiogenese: Ein neuer Ansatz in der Tumortherapie?] Medizinische Klinik 94: 570-579.


22. Huang, X., C. Gottstein, R.A. Brekken, P. Thorpe (1998) Expression of VEGF receptor 2 and characterization of its binding to VEGF via surface plasmon resonance. Biochemical and Biophysical Research Communications 252: 643-648. BBRC 1998 - PDF


23. Derbyshire, E.J., C. Gottstein, P. Thorpe. (1997) Immunotoxins. In: Immunochemistry 1: A practical approach. M. Turner, A. Johnston (Hrsg.) Oxford University Press, 239-273.


24. Gottstein, C., G. Schön, S. Tawadros, M.L. Hansmann, F. Berthold, A. Engert. (1996) A disseminated human neuroblastoma model. In: Immunodeficient Animals: Models for Cancer Research. Contributions in Oncology Vol 51, W. Arnold, P. Koepf-Maier, B. Micheel (Hrsg.) Karger, 193-197.


25. Engert, A., C. Gottstein, H. Bohlen, U. Winkler, G. Schön, O. Manske, R. Schnell, V. Diehl, P. Thorpe (1995) Cocktails of ricin A-chain immunotoxins against different antigens on Hodgkin and Sternberg-Reed cells have superior anti-tumor effects against H-RS cells in vitro and solid Hodgkin tumors in mice. International Journal of Cancer 63: 304-309.


26. Engert, A., C. Gottstein, U. Winkler, P. Amlot, S. Pileri, V. Diehl, P. Thorpe (1994) Experimental treatment of human Hodgkin's disease with ricin A-chain immunotoxins. Leukemia & Lymphoma 13, 441-448.

27. Gottstein, C., U. Winkler, H. Bohlen, V. Diehl, A. Engert (1994) Immunotoxins: Is there a clinical value? Annals of Oncology 5, Suppl. 1: S97 – S103.

28. Kapp, U., A. Dux, E. Schell-Frederick, N. Banik, M. Hummel, S. Mucke, C. Fonatsch, J. Bullerdiek, C. Gottstein, A. Engert (1994) Disseminated growth of Hodgkin's-derived cell lines L540 and L540cy in immune-deficient SCID mice. Annals of Oncology 5, Suppl. 1: S121-S126.

29. Winkler, U., C. Gottstein, G. Schön, U. Kapp, J. Wolf, M.L. Hansmann, H. Bohlen, P. Thorpe, V. Diehl, A. Engert (1994) Successful treatment of disseminated human Hodgkin's disease in SCID mice with deglycosylated ricin A-chain immunotoxins. Blood 83: 466-475. Blood 1994 - PDF Blood Editorial - PDF

30. Gottstein, C., G. Schön, S. Tawadros, D. Kube, U.C. Wargalla-Plate, M.L. Hansmann, H.H. Wacker, F. Berthold, V. Diehl, A. Engert (1994) Antidisialoganglioside ricin A-chain immunotoxins show potent antitumor effects in vitro and in a disseminated human neuroblastoma severe combined immunodeficiency mouse model. Cancer Research 54: 6186-6193. Cancer Research 1994 - PDF